Gonadotropin-Releasing Hormone : Present Concepts, Future Directions

概要

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ABSTRACT-There is an overwhelming amount of evidence to indicate that gonadotropin-releasing hormone (GnRH), a decapeptide , is found in multiple molecular forms , and is vital for the functional integration of brain-pituitary-gonadal axis in vertebrates. In simple terms, there is an overall agreement that GnRH acts as a neuroendocrine regulator of pituitary gonadotropin secretion, gonadal steroid secretion, sexual behavior, and reproduction. GnRHs are distributed widely within the vertebrate body, particularly in the brain. The brain GnRH neuronal system(s) varies in its morphology, ontogenesis and function across vertebrates. It is a highly dynamic structure which does not function at the same level throughout life. A large framework of studies completed to date attests to the emerging concept that GnRH neuronal system is regulated by a complex neural circuitry , comprised of diverse neurochemical signals , which may provide excitatory or inhibitory input to GnRH neurons. While general considerations on GnRH systems may be similar among vertebrates, it must not seduce us to generalize the more specific details. In fact, there may occur ontogenesis and reproductive status-related changes and a timetable of complex neuroendocrine events that are probably (certainly) species-specific.
社団法人日本動物学会の論文
1994-06-15