Abnormal Development of Preimplantation Embryos Derived from Intersubspecific Hybrids between Mus musculus molossinus and M. m. domesticus : Genetics

スポンサーリンク

概要

• 論文の詳細を見る

• Japanese wild mice, Mus musculus molossinus, are genetically remote from laboratry mice which are derived predominantry from European wild mice M. m. domesticus. Our previous study demonstrated that F2 progeny between these two mouse subspecies show low ferility, even though F1 hybrids are fully fertile. In fact about half of the F2 females fail to become pregnant. We examined the in vitro development of preimplantation embryos from F2 progeny between MOM (one of the inbred strains derived from Japanese wild mice) and C57BL/6 (B6, an inbred strain of laboratory mice). We found that the low pregnancy rate of F2 females results from a high embryonic mortality: only 58.4% (66/113) of embryos developed to the blastocyst stage in the F2×F2 cross, whereas in the B6×B6 cross the corresponding figure was 100.0% (23/23). The mortality was not due to defects in sperm from F2 males but rather to defects in the eggs from F2 females: the survival rate of embryos up to the blastocyst stage was 52.2% (82/157) in the F2♀×B6♂ cross, whereas it was 94.9% (74178) in the B6♀ XF2♂ cross. The factors responsible for this mortality are attributable to nucleus, not to maternally inherited cytoplasm: more than 10% of N2 femals derived from backcrossing either Fl femals to B6 males or F1 males to B6 females showed the higher embryonic mortality. This finding suggests that intersubspecies genic combinations, either intragenic or intergenic, give rise to some deleterious effects on the oocytes during oogenesis.

• 社団法人日本動物学会の論文
• 1990-04-15

著者

• Wakasugi N

  Nagoya Univ. Nagoya Jpn

• Wakasugi Noboru

  Laboratory Of Animal Reproduction Graduate School Of Bioagricultural Sciences Nagoya University

• NIWA MICHIKO

  Laboratory of Animal Genetics, Faculty of Agriculture, Nagoya University

• Niwa Michiko

  Laboratory Of Animal Genetics Faculty Of Agriculture Nagoya University

• Wakasugi Noboru

  Laboratory of Animal Genetics, Faculty of Agriculture, Nagoya University

• WAKASUGI NOBORU

  Laboratory of Animal Breeding, Faculty of Agriculture, Nagoya University

関連論文

• Histological and Ultrastructural Features in the Early Stage of Purkinje Cell Degeneration in the Cerebellar Calcification (CC) Rat
• 日本産野生マウス(Mus musculus molossinus)において発見された尾形成異常遺伝子〔英文〕
• Arrest of Spermatogenesis at the Early Meiotic Stage in the Small Testis Mutant (Smt) Mice
• Abnormal Development of Preimplantation Embryos Derived from Intersubspecific Hybrids between Mus musculus molossinus and M. m. domesticus : Genetics
• 日本産ウズラにおける膵臓アミラ-ゼの遺伝(速報)〔英文〕
• STUDIES ON A PLUMAGE MUTANT (BLACK AT HATCH) IN THE JAPANESE QUAIL

スポンサーリンク