Mesenchymal-Epithelial Interactions in the Organogenesis of Digestive Tract

概要

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It is now well established that the mesenchymal-epithelial interactions are essential in the spacio-temporally regulated differentiation processes in organogenesis of higher vertebrates. The mesenchymal-epithelial interactions in the digestive tract (DT) in avian and mammalian embryos have presented precious information on the nature of interaction, because the endoderm that later gives rise to the DT epithelium is a simple sheet consisited of undifferentiated cells at the early stages and with the development of DT the epithelium gradulally acquires region-specific morphology and cytodifferentiation under the influence of the underlying mesenchyme. The studies carried out have demonstrated that the mesenchyme is dominant over the epithelium in determining the morphology of the latter and that the morphogenesis and cytodifferentiation are not always associated. Also the importance of epithelial competence against mesenchymal inductive influence has been repeatedly stressed. In this article we summarize these results and our recent findings to clarify the present status of the problem and to suggest the direction of further investigations.
社団法人日本動物学会の論文
1990-04-15