敗血症性多臓器不全

概要

論文の詳細を見る
We analyzed 3,435 cases of gastrointestinal surgery conducted at our hospital to reveal the relationship between infection and multiple organ failure. We found that infection was deeply related to multiple organ failure. Therapeutic apheresis for severe infection, sepsis or septic MOF was reviewed. Neither CHF nor CHDF, which are popularly chosen as the treatments for sepsis or septic MOF, have not been clearly reported to be effective for sepsis, neither in clincial studies nor in experimental studies. Furthermore, it has not been decided if plasma exchange is clinically useful for sepsis or septic shock. PMX has been developed as a columnar device to remove endotoxin from the blood. A multi-center clinical trial (Phase III) revealed that it is successful to treat sepsis or septic shock by direct hemoperfusion using PMX.
日本アフェレシス学会の論文
1999-02-28