多臓器不全への進展を防止する新しい治療戦略CTR(<特集>多臓器不全とアフェレシス)

概要

論文の詳細を見る
Systemic inflammatory response syndrome (SIRS) is one of the main causes for progression of multiple organ failure (MOF). Hypercytokinemia plays a main role in this progression. It is well known that continuous hemodiafiltration therapy (CHDF) is effective for SIRS. CHDF therapy has a potential for removing the inflammatory related cytokines in SIRS patients. It is indicated that CHDF therapy can improve SIRS and MOF via adsorbing the inflammatory related cytokines. Therefore the adsorption column for inflammatory related cytokines can ameliorate SIRS and MOF via same mechanism as CHDF. It is reported that the β2-microglobulin adsorbent column has the potential for adsorption of the inflammatory related cytokines and improving SIRS. In this paper the possibility of CTR for use in the treatment of SIRS, which was developed for adsorbing inflammatory related cytokines, is discussed.
日本アフェレシス学会の論文
2004-02-29