気管支発癌における前腫瘍性変化

概要

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A variety of epithelial changes were described in the respiratory tract of syrian golden hamsters inhaling tobacco smoke and bronchial autografts of dogs exposed to the carcinogenic aromatic hydrocarbons (3,4-benzo(a) pyrene, 3-methylcholanthrene). These respiratory epithelium were examined by high-resolution light and electronmicroscopy. Squamous metaplasia with atypia were significant links in the evolutionary chain of events leading to the development of the carcinoma occuring in the major bronchii. The problems were discussed to identify the earliest stages in the evolution of respiratory tract neoplasia and to permit therapeutic intervention before progression to invasive neoplasia. We feel that recent progress of the experimental respiratory carcinogenesis, especially the method using localized modes may be usefull experimental approach for these problems identifing the earliest neoplastic epithelial changes.
日本肺癌学会の論文
1980-03-31