The effect of the ultrasonic irradiation on clearance in dialyzer-model

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In the dialysis experiment where an artificial kidney was used as a model, and an aqueous solution of creatinine was used instead of blood, the clearance, dialysis efficiency, was improved remarkably by ultrasonic irradiation. The clearance increased with the ultrasonic level and raeched the maximum value at a certain ultrasonic level. The maximum value of clearance was about 1. 5 times as high as that without ultrasonic irradiation. The dialysis in this dialyzer model was treated with a simple transfer theory on the inside of the dialyzer tube wall, and in the outer region of the tube considering the diffusion resistance respectively. The derived relation of clearance to the volume flow was compared with the experimental results. It has been deduced that the higher values of the clearance were due to the removal of the outer concentration boundary layer by ultrasonic cavitation and microstream. Thus, the predominated resistance was considered to be mainly due to that in the tube wall in this situation, and the value of diffusion coefficient was about 7. 7×10^<-7>cm^2/s.
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