尿管活動電位の研究 : Extraluminal Electrodeによる実験的臨床的検索

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The animal and clinical experiments of studies on the action potential of the ureter were performed with an improved extraluminal electrode, which the author has deviced (Fig. 1 in Japanese text). At first thus recorded wave of the action potential of the ureter was compared with the theoretically induced wave (Table 9 in Japanese text), and the accordance with each other was fairly confirmed. The important indicators that represent physiological conditions of the ureter are period of the wave (P), velocity (v), amplitude of the spike (Vp max), polarization power of smooth muscle fiber of the ureter (K) and the interval between spike maximums in the action potential wave (T"). The results are as follows: 1) The ureteral peristalsis of the rabbit is not distinctly affected by administration of some drugs acting on the autonomic nerve system (vagostigmin, besacholin, buscopan, atropin sulphate, opistan and papaverine hydrochloride). 2) In the normal ureter of the morphologically and functionally normal upper urinary tract, fairly constant action potential waves of the antegrade peristalsis are recorded, but waves of the antiperistalsis do not appear. In general tendency, P is small when K is big and the reverse phenomena. 3) The action potential in the hydroureter due to urinary obstruction is not, or only weakly recorded. If recorded, the value of P and v is inconstant, and the action potential generally has a tendency to show big T" and small K and Vp max. Whereas, in the action potential wave of the ureter below obstruction, the antiperistalsis is recorded at a pretty high rate. 4) Particularly, in cases of the renal calculi (calculus in calyx or pelvis of the kidney, staghorn calculus), antiperistalsis is frequently recorded, if the ureter is functionally and morphologically normal. The antiperistalsis can be also evoked with ease by means of operative procedure, e.g. lithotomy. The appearance of antiperistalsis is calssified into two types: (i) antiperistalsis alone, (ii) antiperistalsis co-existing with antegrade peristalsis. In the transition between antegrade peristalsis and antiperistalsis, distinct regularity can not be confirmed. But when both antegrade peristalsis and antiperistalsis coexist, v, Vp max, K of the latter are smaller than those of the former. 5) Although linear incision is added on the ureter and the most possible of the urine is permitted to flow out, action potential of the ureter below the incision can be recorded, if action potential exists above the incision. 6) In severe ureteritis, especially in tuberculous ureteitis, the action potential wave is not recorded.
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尿管活動電位の研究 : Extraluminal Electrodeによる実験的臨床的検索

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