モルモツト膀胱運動に対する交感神経の抑制機構に関する実験的研究

概要

論文の詳細を見る
The recent histochemical researches have revealed that the sympathetic nerves innervated to the vesical muscle directly, but also some of them ended in the parasympathetic ganglion in the urinary bladder. In the present study, a series of experiments were made to find out how the above mentioned two types of sympathetic nerve supply act on the spontaneous contraction and the phasic contraction induced by pelvic nerve stimulation in guinea pig bladder, since the former contraction is responsible for the retention of urine and the latter is for the urination. As a result, the frequency of spontaneous contraction and the associated muscle tone were reduced by the section of the pelvic nerve. However, these changes were not influenced by the subsequent section of the hypogastric nerve. In contrast, if the hypogastric nerve was cut initially, the frequency and muscle tone were increased markedly and the effects of subsequent section of the pelvic nerve were the same as those by section of the pelvic nerve alone. When repetitive electric stimulation was given to the hypogastric nerve, the frequency of spontaneous contraction was reduced with a fall of the muscle tone, though such effects were not produced after section of the pelvic nerve. After application of α-blocking agents, the reduction of spontaneous contraction due to hypogastric nerve stimulation disappeared. Repetitive electric stimulation of pelvic nerve augmented the frequency of the spontaneous contraction and muscle tone. Furthermore, such effects were intensified by section of the hypogastric nerve. Thus this kind of inhibition induced by the hypogastric nerve was only produced in the presence of the pelvic nerve supply. From these results it was estimated that this kind of inhibition of the hypogastric nerve on spontaneous contraction might be a ganglionic inhibition which act on α-adrenergic receptors. Phasic contraction was induced by electric stimulation of the pelvic nerve and it was partially blocked by atropine or by dTC. The submaximal contraction was not influenced by the absence or presence of the hypogastric nerve, though this contraction was inhibited by electrical stimulation of the hypogastric nerve and this effect disappeared after treatment with β-blocking agents. Therefore, phasic contraction induced by pelvic nerve stimulation is considered to be controlled by the direct inhibition of the sympathetic nerve and this effect was blocked by β-blocking agents. From these observations it was concluded that the sympathetic inhibition to vesecal muscle was revealed by two different manners, one is the depression of the impulse flow in the post ganglionic pelvic nerve and the other is the depression of vesical muscle.
社団法人日本泌尿器科学会の論文

モルモツト膀胱運動に対する交感神経の抑制機構に関する実験的研究

スポンサーリンク

概要

著者

関連論文

スポンサーリンク