腹膜の透過性に関する研究 : 各種物質についての比較
スポンサーリンク
概要
- 論文の詳細を見る
Apparent permeability constants of peritoneum and artificial kidney twin-coil were determined by the multiple tracer method using ^<24>NaCl, ^<42>KCl, ^<14>C-urea, THO and ^<14>C-mannitol in the way previously reported<4)>. The experimental data shown in Tables 3 and 6 were obtained from 9 adult patients, consisting of 6 patients examined by ^<24>NaCl, ^<42>KCl, THO, and ^<14>C-urea, and 3 by ^<24>NaCl and ^<14>C-mannitol, and from 3 twin-coils examined by ^<24>NaCl, ^<42>KCl, THO and ^<14>C-urea. From these data, the following conclusions were obtained. 1) The apparent permeability constants of H_2O, urea, K and mannitol are in average 2.42, 1.44, 1.40 and 0.656 times as large as that of Na respectively. Those of K, Na and mannitol are in proportion to their diffusion constants in water. On the other hand, peritoneal permeability of urea and H_2O is greater than expected from their diffusion constants in water. 2) On the assumption that, mannitol does not penetrate the cell-wall and that, it passes through the intercellular space of the peritoneal membrane by simple diffusion, it is considered that, H_2O, urea, K and Na pass for the most part through the intercellular space of the peritoneal membrane by simple diffusion and that a small amount of H_2O and urea is transported through the peritoneal cell-wall. It is strongly suggested that, the transfer of these substances through the peritoneal membrane is carried out by "passive transport". 3) Peritoneal clearance and dialysance of an artificial kidney can be calculated at any flow rate from apparent permeability constants of the peritoneum and twin-coil. Their relationships are shown in Fig. 5 and 6. Peritoneal clearance and dialysance of an artificial kidney increase in accordance with the increase of the flow rate, and approach their apparent permeability constants at the infinite flow rate. These maximum urea and K dialysances of an artificial kidney are about 7 times as large as those of peritoneal clearance. 4) When intermittent peritoneal dialysis is done using a liter of dialysate at a time, average 28.4 minutes are required for the inflow and outflow of the dialysate. To get maximum efficacy, it is desirbale to perform one peritoneal dialysis by an intermittent technique about 40 minutes from the beginning of inflow to the end of outflow of the dialysate.
- 社団法人日本泌尿器科学会の論文
著者
関連論文
- 排尿障害の流体力学的検討 : 前立腺肥大症における膀胱仕事量, エネルギー損失率, 膀胱壁収縮速度, 膀胱壁張力, 尿道抵抗の術前, 後の変化
- 25年経過し,その間に自然分娩に成功した尿管S状結腸吻合の1例
- 東大泌尿器科8年間の疾患統計
- 尿路結石の臨床統計
- 腎尿管腫瘍の治療成績
- 右副腎褐色細胞腫摘除10年後に再発した褐色細胞腫の1例
- 腹膜の透過性に関する研究 : 各種物質についての比較
- 東京大学泌尿器科教室における1962年度外来入院患者及び手術術式の統計的観察
- 東京大学泌尿器科教室における1961年度外来, 入院患者及び手術術式の統計的観察
- 腎血管性高血圧における分腎機能検査
- 濃縮試験における尿滲透圧
- 腹膜の透過性に関する研究 : 方法論を中心として
- 手術侵襲の体液量への影響 : Tracer kineticsによる分析
- アスパラギン酸ルビジウムの血球取り込み
- 急性間質性腎炎による急性腎不全の1例