泌尿器科領域に於ける原発性副甲状腺機能亢進症の研究 : 第V編 : 実験的副甲状腺機能亢進症並びに原発性副甲状腺機能亢進症患者の腎臓に於ける無機燐の動態について

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The effect of parathyroid hormone for renal tubular transport mechanism of inorganic phosphate was investigated by clearance and stop-flow techniques in dogs and in total of fifteen clinical patients. Administration of parathyroid extract to the parathyroidectomized dog resulted in a significant increase in the excretion of phosphate by inhibiting the reasorption in the proximal tubule. Comparing the pattern of the stop-flow analysis in the parathyroidectomized dog with that in the intact one after calcium infusion, it was suggested that parathyroid extract has a direct phosphaturic effect on the renal tubule. This conclusion is assumed to be in agreement with the results of the following Procedure. When the parathyroid extract was given by the way of the left renal artery at a relatively high dose, phosphaturic effect was rapid and essentially identical in both kidneys. On the other hand, at a low dose, the changes in the stop-flow pattern were confined only to the infused kidney. In the clinical studies, clearance test and stop-flow analysis were performed before and after parathyroidectomy in the seven kidneys which appeared to be normal in urogram in the patients with primary hyperparathyroidism. The main functional change in the kidney, which was induced by excess of parathyroid hormone, seemed to occur at the proximal tubules. This change was similar to that of the result in animal experiment. The functional damage in the tubules might be reversible. Since the normal stop-flow pattern was obtained immediately after parathyroidectomy. No remarkale changes were found in the stop-flow patterns in the patients with urolithiasis due to other causes, as in the normal kidneys of the patients with cystitis and hydrocele.
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泌尿器科領域に於ける原発性副甲状腺機能亢進症の研究 : 第V編 : 実験的副甲状腺機能亢進症並びに原発性副甲状腺機能亢進症患者の腎臓に於ける無機燐の動態について

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