家兎ノ全身黴毒症状ニ就テ
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概要
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Many have been thn rsports concerning the symptoms of the generalized syphilis in the rabbit, i.e. alopecia, rhagades about the hares, changes of the claw, various skin erruptions, nose tumors, conjunctivitis, keratitis etc. The author observed also the symptoms of generalized indection as described in this paper to appear among the rabbits of experimental syphilis. The Treponema pallidum was inoculated in the testicle or skrotum. The symptoms were: 1) Alopecia in two cases appeared from about 11 to 19 weeks after the inoculation. Both died from emaciation, when this symptom was still present. 2) Swelling, in the region of the nose-glistle in one case appearing after about 14 weeks of the inoculation. The swelling was hard and pigeon-egg in size. The rabbit lived for 25 weeks mors, during which time the pallidian was always proved in the punctured fluid. 3) Erruptions of the skin in 13 cases. They took reddening, crustattion, desquamation and healing by cicatrisation with various incubation (for 8 to 20 weeks) and duration (for 8 to 16weeks). They varied in form. At the maximum, they were as large as .bean of pigeongg; some were conical, with dark gray, oyster shell-like crusts on the top(Fig. 3), some were round with the flat crusts(Fig. 4), and the other had the appearance of chancle(Fig. 2 and 5) agreeing with previous authors' reports on papulous syphilides or Papd ulcerosa. The spirochater were present in all papules. The number of erruptions was mostly 3 to 4, but varied from 1 to 10 in some cases. Favorite site of the. erruptions was the face, head, limbs, anal lesion and precipuce, often taking symmetrical positions (Fig. 1). Among 155 rabbits which produced typical primary lesions and lived for more than 8 weeks after inoculation, 13 cases of metastic erruptions were observed. But exact percentage can not be deduced from it, since many of them were employed for the therapeutic purpose precociously. The metastic papules were inoculated into the normal rabbits, but no increase of the percentage of appearing of the erruptions was obtained in this way. Luetic serum reaktions: There was no difference in the intensity of Wassernann or precipitation reaction between those rabbits, which showed the general symptoms and those which had only the primary lesions.
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