尿路結石溶解の研究

概要

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Thin slices of urinary calculi were prepared, and the chemical compounds were analized and the structural patterns were observed. These observations were mineralogically performed by the polarization microscope. From this study, the mixed stones having chemical compounds, weddellite, whewellite and apatite, were encountered most frequently. Then this slice of stone was placed in the solvents in vitro and the process of its dissolution was observed by the polarization microscope. By this study, it was found that struvite was most soluble. Solvability order of the chemical compounds of urinary calculi was as follow, struvite, apatite, weddellite, whewellite, uric acid and cystine. Uric acid and cystine were paticullary difficult. Regarding solvents, tetrasodium E.D.T.A. was the most effective and then ordered as follow, dosodium EID.T.A., renacidin, solution G, solution M, gurcuronic acid and urease. Gurcuronic acid and urease did not show any dissolution reaction, but slight reaction to struvite. The stone of which the main compound is struvite, was soluble to acid solvent. The stone of which the main compound is apatite, was not related to pH and the stones having main compounds of weddellite, whewellite, uric acid and cystine, were soluble to alkaline solvent.
社団法人日本泌尿器科学会の論文