尿生成の日内変動に関する研究

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In order to investigate diurnal rhythm of urine excretion, 47 patients were studied. The results are summarized as follows : l) The excretory patterns of urine volume during 24 hours in usual life were classified into five types. They are the nocturnal oliguric type, 9 p.m.-3 a.m. oliguric type, 0 a.m.-6 a.m. oliguric type, nocturic type and flat type. The subjects without renal insufficiency showed the nocturic type invariably. 2) In the subjects without renal insufficiency, two excretory patterns of total solute were noticed, the first type with maximum excretion at noon, the second type with maximum excretion in the morning and evening, in contrast with various types of volume. 3) The graphic relation between urine volume and total solute excreted in hourly fraction of urine in usual life clarified the facts that there were two groups independent of types of excretory pattern of volume, one showing a straight line in distribution and the other showing a shift to the right. The total solute in fractions of urine at night was less than that in daytime in each group. 4) Two subjects were kept under a constant water load. From the observation of graphic relation between urine volume and total solute excretion in this experiment, the shift of fractional urine to the right was revealed to be water diuresis. 5) Three subjects were kept under a constant water load and pitressin was injected subcutaneously, and then each subject reached the state of osmotic diuresis in maximum antidiuresis by exogenous ADH. One subject received constant infusion of 2.5% saline under restriction of water. He represented osmotic diuresis in maximum antidiuresis by endogenous ADH. From the observation of graphic relation between urine volume and total solute excretion in these experiments, straight linear distributions were thought to be chiefly due to osmotic diuresis.
社団法人日本泌尿器科学会の論文

尿生成の日内変動に関する研究

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