Prostaglandinと腎機能 : 第3報 Prostaglandin A_2と尿中溶質排泄

概要

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1) Twenty-nine cases without upper urinary tract dilatation and renal impairment were studied on urinary solutes excretion induced by PGA_2. 2) An intravenous infusion of PGA_2 with the rate of 400 ng/Kg/min. caused marked increases of urine volume and urinary excretion of both sodium and chloride. Especially as for sodium excretion, more increase was observed among hypertensives than normotensives. 3) The same effect of PGA_2 was observed at the state of dehydration followed by an intramuscular injection of 5 units of vasopressin. U_<osm$gt; decreased slightly, while C_<osm> and T^C_<H_2O> increased. 4) These effects of PGA_2 on urinary solute excretion were supposed to be due to the fact that PGA_2 increases the renomedullary blood flow and inhibits the sodium reabsorption at the proximal tubuli.
社団法人日本泌尿器科学会の論文
1974-10-20