プロスタグランデインと腎機能 : 第2報プロスタグランデインE_1の腎動脈内投与によるヒト選択的腎動脈撮影像について

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By the use of selective renal arteriography, the effect of PGE_1 on arteriogram was studied in 30 patients with hematuria. Renal arteriography before and after injection of 50 mcg of PGE_1 into the renal vascular bed revealed the following results. 1) At the moment of 0.5 second after the initiation of injection of contrast medium, it advanced more peripherally after the PGE_1 injection compared to the control study. In some cases, maximal arterial phase appeared earlier with PGE_1 than without this agent. 2) The maximal nephrogram was visualized earlier after PGE_1 injection than control. When the size of the nephrogram was compared, it was enlarged when PGE_1 was used. 3) The maximal visualization of renal vein occurred earlier with PGE_1 than the control study. 4) Dopamine (500 mcg) was also shown to have approximately same effect as PGE_1 (50 mcg). As shown in this study, the vasodilative effect of PGE_1 was successfully demonstrated by means of radiological method. These results suggest that PGE_1 might be a useful pharmacologic adjunct in renal arteriography. Furthermore, PG could be a good therapeutic agent in the case of an inadequate renal circulation caused by shock or operation of kidney.
社団法人日本泌尿器科学会の論文