ラット精管β-Adrenergic Receptorとの関連におけるCyclic AMP値の変動とその意義

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概要

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• Adenosine 3', 5'-cyclic monophosphate (cyclic AMP), discovered by Sutherland et al. in 1958, is now considered to be the secondary messenger of various β-adrenergic actiohs, such as cardiac inotropic action, glycogenolysis, lipolysis and relaxation of several smooth muscles. (1) Many investigators have already detected the presence of inhibitory β-adrenergic receptors in the vas deferens of some mammals. (2) Phosphodiesterase inhibitors (i.e. aminophylline, theophyl-line and papaverine) can reduce br abolish contractions of the vas deferens or rabbits, guineapigs and rats. (3) Externally applied dibutyryl cyclic AMP, a derivative of cyclic AMP, can reduce or abolish contractions of the vas deferens of guinea-pigs, rats and humans. From the above-mentioned previous reports by many authors, it may be suggested that cyclic AMP is the intracellular mediator of inhibitory β-adrenergic action of the vas deferens smooth muscle. In this paper, changes ih tissue cyclic AMP levels of the rat vas deferens following administration of catecholamines, adrenergic blocking agents and aminophylline have been observed. The methods were as follows : 1) 9 weeks old male Wistar rats (216±21g), anesthetized with sodium pentobarbital 50 mg/kg i.p., underwent lapalotomy. 2) A drug or drugs were injected into the vena cava inferior. 3) 3, 8, 15, 30 or 60 minutes after the injection, the total length of both vas deferens was excised. 4) Immediately cyclic AMP levels of each tissue were estimated, using the cyclic AMP Assay Kit (Radiochemical Centre, Amersham, England)..

• 社団法人日本泌尿器科学会の論文
• 1978-12-20

著者

• 奥村 哲

  日本医科大学 泌尿器科

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