口腔軟組織の Cytotoxin に関する研究
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The percent emulsion in saline of rat's gingival tissiue slice was injected into rabbit's ear vein in amount of one to two ml twice to 18 times, and high production of the antibody against the tissue was confirmed in the latter animal by means of precipitation and complement-fixation reactions. It was confirmed that by injecting the rabbit's antiserum into the caudal vein of healthy rats, a gingival lesion to be observed even by the naked eye could be produced. It was decided, therefore, that this substance be named "Gingivotoxin" to be ranked in a member of the cytotoxins affecting specifically gingiva. The results of the study are summarized as follows. 1) When the animals were subjected to immunization with the saline emulsions of gingiva (G group), of parotid (P group) and of tongue (Z group), the rates at which they died of shock were respectively 63.5 percent in G group, 50 percent in P group, and 40 percent in Z group. 2) The pathological processes occurring in G group of animals were primarily different from those observed in the other groups in that there appeared in the basement membrane at the interdental papillae severe anemia and epithelial cysts accompanied by cellular infiltration of the epithelia. The cysts enlarge, and with that enlargement comes liquefaction of the tissue involved which finally leads to necrosis of Sharpey's fibers. 3) In parallel with these macroscopic lesions seen in the gingival tissue, there were observed microscopically relatively weak changes taking place in such organs as spleen, kidney and lung whereas no change was detected occurring in the hard tissue and the pulp of teeth even by microscopic examination. The results of the experiment suggested a possibility that such a necrotic lesion of gingiva and periodontal membrane might be somehow induced also by the action of autotoxin of gingiva according to the theory of inverse allergy or metallergy, and if this happens, the present study may serve to lend a support to the allergic theory for the ethiology of one type of socalled pyorrhea alveolaris.
- 九州歯科学会の論文
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