輸血節減下手術時の循環動態に関する基礎的研究
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As one of the basic investigations on the reduced blood transfusion at the surgical operation which has been deviced in our clinic, 1 studied the state of the circulatory system of (I) normal dogs and (II) poor-risk dogs (the body weight reduced 10-15% ; Hb. 65-50% ; blood-plasma albumin 6.5-5.0g/dl) when they underwent a large quantity of depletion ((I) : 20cc/kg ; (II) : 10cc/kg) after the lumbar anesthesia potentiated by Cocktail ; and then investigated the extent to which the injection of the same quantity of Alginon improved the state of the circulation ; and I have obtained the following results. (I) (Normal dogs ; 20cc/kg depletion) (1) The femoral arterial pressure was reduced 39.7%, the circulating blood volume decreased by 33.8%, and the state of bloodgases were in a anoxemia and hypercapnia, and so a considerable hindrance of circulation was observed. (2) (20cc/kg Alginon injection) The recovery of the femoral arterial pressure, the circulating blood volume and the bloodgases was more remarkable than in the case of the 5% gulcose injection. But a 15.9% decrease of the femoral arterial pressure and 15.0% of the circulating blood volume were still observed in 5 hours after the injection of Alginon. The Alginon injection proved to be more efficient than the 5% gulcose injection in that the hemodilution was slight and the recovery of the oxygen consumption was favourable. As to the blood-plasma albumin and the temperature, no significant differences were recognized between the two groups. But by the Alginon injection the state of the circulation could not be completely restored to the normal level. (II) (Poor-risk dogs ; 10cc/kg depletion) (1) The femoral arterial pressure was reduced 36.8%, the circulating blood volume decreased by 28.0% and the blood-gases were tended to anoxemia and hypercapnia. So, as in the case of (I) (1), a remarkable hindrance of circulation was observed. (2) (10cc/kg Alginon injection) The circulation which had become worse after the depletion was considerably restored. The state of the femoral arterial pressure, the circulatory blood volume and the bloodgases were admittedly more improve than in the case of the 5% gulcose injection, and besides the hemodilution was hardly observed. But a 16.2% decrease of the femoral arterial pressure and a 11.1% of the circulating blood volume were still observed, and so the state of the circulation could not be recovered to the former level.
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