下歯槽神経再生に関する実験的研究
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概要
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With use of 33 mongrel adult dogs, the inferior alveolar nerves in the mandibular bone defect made and covered with a silicon sheet were resected experimentally, and the group with the inferior alveolar arteries and veins resected and the group with those retained were compared histopathologically. Granulation in the bone defect started from three days after operation in both the vas-resected group and vas-retained group. All blood clots were replaced by granulation tissue in 30 days in the vas-resected group and in 21 days in the vas-retained group. Neogenesis of bone was seen from five days after operation in both groups. Although the amount of new bone was slightly greater in the vas-retained group, continuation of new bone was not seen in either group even 90 days after operation. The cause of this was attributed to the blocking-off of the periosteum by the silicon sheet. In the vas-resected group, no neogenesis of vessels was seen from the trunk of the inferior alveolar artery which was resected with the artery ligated, and neogenesis of vessels was thought to be from the resected ends of branches of the inferior alveolar artery. Retrograde degeneration of nerve fibers was seen from one day after operation in both groups. No marked differences in the extent and time of degeneration were seen between the two groups and the course of degeneration was similar to those reported previously. Wallerian degeneration of nerve fibers was seen from one day after operation and reached a peak from five to seven days after operation, and the degenerated nerve fibers about disappeared 21 days after operation. Around the degenerated nerve fibers, macrophage-like cells were observed and these cells were thought to be involved in phagocytosis. Proliferation of Schwann cells was seen from five days after operation in both groups and the direction of proliferation of Schwann cells was more linear in the vas-retained group than in the vas-resected group. Extension of regenerated nerve fibers was seen from seven days after operation, following the proliferation of Schwann cells, and the resected ends were connected in 30 days after operation. The direction of regeneration of nerve fibers was more linear and the number of nerve fibers reaching peripheries was greater, and thicker fibers were found more in the vas-retained group than in the vas-resected group. On the basis of the foregoing findings, importance of the role played by the blood vessels accompanying regeneration of nerves was indicated.
- 九州歯科学会の論文
- 1989-02-25