口腔扁平上皮癌患者の cytokeratin 19 fragment に関する臨床的研究
スポンサーリンク
概要
- 論文の詳細を見る
Cytokeratins are intermediate filaments which are part of the cytoskelton of both normal epithelia and their malignant counterparts. The fragment of cytokeratin subunit 19 (CK) has been reported as a new marker in non-small cell carcinoma of the lung. However, there have been no reports of a valuable tool for diagnosis, prognosis, treatment monitoring, and combination assay in oral squamous cell carcinoma (O-SCC). CK was determined by a solid-phase immunoradiometric assay based on the two-sandwich method in the serum of 50 patients with O-SCC, 20 patients with oral benign diseases, and 10 healthy controls. The patients were segregated into two groups. The good-prognosis group consisted of 32 patients completely free from cancer for more than 1 year after primary treatment. The poor-prognosis group was composed of 18 patients with local recurrence or regional lymph node metastasis. Serial measurements of CK were pretherapeutically available in 20 patients as well as during individual therapy and follow-up. Serum samples were obtained at the time of primary diagnosis and after treatment, as well as at least once postoperatively. The results were as follows : 1. The mean serum concentration for patients with O-SCC (2.24±2.55ng/ml) was significantly higher than that of 20 patients with oral benign diseases (1.38±0.77ng/ml) and of 10 healthy controls (1.17±0.41ng/ml). 2. The mean serum concentrations of CK were significantly lower in the good-prognosis group (1.76±1.25ng/ml) as compared to the poor-prognosis group (3.08±3.83ng/ml). When good control of cancers was obtained, the serum level of CK returned to normal. When local recurrence or metastasis could be clinically detected, the serum level of CK went down to normal or near-normal levels, but it showed a higher level as compared with the good-prognosis group ; all but one of these patients had a normal level. 3. CK evaluation in O-SCC is a valuable tool as a tumor marker for diagnosis, prognosis, and treatment monitoring.
- 九州歯科学会の論文
- 1995-10-25
著者
関連論文
- 小児における粘液嚢胞の臨床統計的観察
- 上顎洞に発生した粘液嚢胞の 1 症例
- 最近の教室における口腔腫瘍の臨床的観察 : エナメル上皮腫例
- 下唇に発現した脂肪腫の 2 症例
- Formocresol (F.C.) の経日変化に関する研究 : 2. 薬瓶(歯科用)中に保存した場合の Formaldehyde の経日変化について
- 先天性側頸嚢胞の 1 例
- 口腔扁平上皮癌患者の cytokeratin 19 fragment に関する臨床的研究
- 上顎に発現したエナメル上皮腫の1症例