口腔扁平上皮癌における増殖細胞核抗原 (PCNA) による免疫組織化学的研究
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The growth activity of cancer cells in oral squamous cell carcinoma plays a key role in the biochemical behavior of tumor tissue. Immunohistochemical examination of proliferating cell nuclear antigen (PCNA) is thought to be a simple method to investigate proliferating activity of tumor cells. The proliferative capacity of the oral squamous cell carcinoma (SCC) was analyzed immunohistochemically using monoclonal antibody against PCNA. The PCNA-positive cell was detected in all cases of formalin-fixed, paraffin-embedded specimen from SCC, oral leukoplakia and normal oral epithelium. The results were as follows : 1) The percentage of the PCNA-positive cells in oral SCC was 17.6±8.5% (n=40) as mean value, and this score was closely related to PCNA scores of oral leukoplakia, of which the mean was 16.2±13.2% (n=30). There was a significant difference in PCNA score between malignant and benign lesions ; 17.6±8.5% (n=40) for oral SCC, 3.9±2.1% (n=10) for normal oral epithelium. 2) There was no correlations between the rate of PCNA-positive cells and the degree of epithelial dysplasia of oral leukoplakia. 3) In oral SCC, there was no significant correlation between the rate of PCNA-positive cells and the stage of the disease, the TNM status. 4) In oral SCC, the rate of PCNA-positive cell correlated with the histological differentiation, the mode of invasion and the grade of malignancy. 5) These results suggest that the PCNA-positive cell rate provides an important information for planning the proper therapy and in predicting the early recurrence and prognosis of patients with surgically resected oral SCC.
- 九州歯科学会の論文
- 1995-02-25
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