虚弱下顎骨に対するカルシトニン, 活性型ビタミン D_3 の併用療法に関する実験的研究
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概要
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Male Wistar rats, three weeks old, were given calcium deficient food and bone debility was induced in them. Then, a treatment method combining 1α-OH-D_3 (0.1μg/kg, orally), an analog of active vitamin D_3, and ECT (0.2μg/kg, intramuscularly), an eel CT inducer, was used for four weeks, and the effect of the treatment method on debilitated mandibles was examined. The results were as follows : 1. Radiological bone density findings The control group showed an average of 1.41 mm, calcium-deficient diet group 0.98 mm, VD_3 group 0.40 mm, ECT group 0.43 mm, and the combination group 0.50 mm. A significant difference was found between the control group and the other four groups with 1% significance level, and the control group showed higher values. 2. Analytical findings of Ca and P on the X-ray analyzer Quantitative analysis by point analysis of Ca and P showed a significant difference with 1% significance level between the control group and the other four groups and the control group showed higher values. 3. Histopathological findings The four experimental groups as compared with the control group showed bone resorption in excess of bone formation and marked decrease of trabeculae in the lingual alveolar bone adjacent to periodontal membrane and in the alveolar bone adjacent to enamel organs, over the whole mandible. The VD_3 group and ECT group as compared with the calcium-deficient diet group showed about the same findings and the Haversian system in spongy bone was not found. In the combination group as compared with the VD_3 group and ECT group, increase in bone lacunae in compact bone was marked and the bone layer thickened. In the four groups exclusive of the control group, the alveolar bone adjacent to the enamel organs showed makedly homeostatic impairment of minerals due to calcium deficiency and extensive bone resorption due to involvement of stimulations from occlusal pressure and eruption of teeth, on the whole area. On the basis of the foregoing findings, bone remodeling is difficult to achieve with VD_3 and ECT used alone or in combination for debilitated bone. It was suggested that they function in a subsidiary capacity with inclusion of calcium and promote activation of bone remodeling.
- 九州歯科学会の論文
- 1993-12-25