根尖性歯周炎とサイトカイン : 根管滲出液中のインターロイキン 1 (IL-1) 様活性物質の検討

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An investigation was made on interleukin-1 (IL-1) -like activity in the exudates from infected root canals of patients with apical periodontitis. The results were as follows : 1. IL-1-like activity was seen in 8 cases among 22 cases with periapical lesions. Six of these 8 cases were in the acute inflammation phase. 2. IL-1-like activity in periapical exudates from patients with apical periodontitis measured about 1/10 that in gingival crevicular fluid from patients with marginal periodontitis. 3. On gel filtration chromatography, the molecular weight of IL-1-like factors in periapical exudates was about 10, 000 daltons. 4. In the experiment of neutralization using anti-IL-1 α antiserum, IL-1-like activity in periapical exudates was inhibited by about 20-30%. IL-1-like activity in gingival fluids, however, was completely blocked. In the same experiment using anti-IL-1 β antiserum, IL-1-like activity in periapical exudates was suppressed by about 50%. Therefore IL-1 β antiserum was more successful than IL-1 α antiserum in suppressing IL-1-like activity in periapical exudates. 5. IL-1-like activity was diminished following successful endodontic treatments. However, when endodontic treatments did not produce good results in the patient, IL-1-like activity continued to be present in periapical exudates. The above findings suggest that an IL-1-like factor exists in periapical exudates and it may relate to the degree or the condition of the periapical lesions.
九州歯科学会の論文
1991-04-25

根尖性歯周炎とサイトカイン : 根管滲出液中のインターロイキン 1 (IL-1) 様活性物質の検討

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