活性型ビタミン D (1α-OH-D_3) の歯槽骨に及ぼす影響に関する実験的研究
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For the purpose of clarifying the effect on the alveolar bone and tibia at growth stage of administration of 1α-OH-D_3, an analogue of active type vitamin D (0.05μg/kg 3 times a week and 0.1μg/kg 3 times a week), sixty male rats of Wistar strain, 5 weeks old, were examined for weight, and radiologically, optically, photo-densitically, histopathologically and hemologically. The results were as follows : 1. From one week after the start of the experiment, the rats in the control group, 0.05-group, and 0.1-group all gained weight with time in the experiment. However, the 0.05-group and 0.1-group were slightly behind in gain. 2. Radiologically, flunctuations with time in bone density of the alveolar bone was seen in the control group, 0.05-group, and 0.1-group. The two experimental groups showed higher bone density than the control group. In the tibia, the interosseous cortex and medial cortex of 0.05-group and 0.1-group showed higher bone density than those of the control group. 3. Optically, densitic curves for the alveolar bone of the 0.05-group and 0.1-group rose showing undulations from the second week. In the tibia, the densitic curves representing the interosseous cortex and medial cortex of the 0.05-group and 0.1-group were higher than those of the control group from the second week and changed from acute to obtuse in curvature. 4. Photo-densitically, density for the alveolar bone of the 0.05-group and 0.1-group was always higher than that of the control group. Density for the alveolar bone of the 0.1-group was higher than that of the 0.05-group except for the third week. In the tibia, density for the interosseous cortex of the 0.05-group and 0.1-group was higher than that of the control group and density increased gradually with experiment time. Density of medial cortex however showed variations. 5. Histopathologically, the alveolar bone of the 0.05-group and 0.1-group prolifered toward the periodontal membrane and the crest of alveolar ridge was thicker than that of the control group. The interosseous cortex of the 0.05-group and 0.1-group showed bone proliferation toward the periosteum and bone marrow. The medial cortex showed bone proliferation of periosteum and was thicker than that of the control group. 6. Hemologically, the 0.05-group showed lower AL-P values than the control group at the second week. The 0.1-group had higher AL-P values than the control group. At the fourth week, the 0.05-group and 0.1-group showed higher serum C1 and 0.05-group showed higher SLDH than the control group. Administration of 1α-OH-D_3 causes bone proliferation in the alveolar bone and tibia. The alveolar bone showed more complicated changes in bone proliferation process than the tibia depending on administration dosage of 1α-OH-D_3. Administration of 1α-OH-D_3 is expected to improve bone debility of the alveolar bone.
- 九州歯科学会の論文
- 1987-02-25
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