実験的骨粗鬆症に対する食餌の影響に関する研究 : とくに歯槽骨の変化
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概要
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Sixty young male Wistar rats, weighing 40g were used. Twenty animals were fed on a standard diet, 40 on a calcium-deficient diet. Latter group resumed a standard diet after three weeks. The effects of dietary content on the growing alveolar bone and tibia were investigated for weight, radiologically, optically, photo-densitically, histopathologically, and hematologically. The results were as follows : 1. The rats in the experimental group showed considerable increase in weight four weeks after the experiment (one week after resumed a standard diet). Thereafter they showed a significant tendency for increase with time although there was some difference as compared with controls. 2. Radiologically, trabeculae increased in the alveolar bone of the rats of the experimental group, and marked increase in thickness and density of the alveolar bone was seen six weeks after the experiment. In the tibia, interosseous cortex and medial cortex thickened and trabeculae increased in number and became dense. 3. Optically, the inferior portion showed higher densitic curves than the superior portion and this tendency continued until the sixth week although the difference became smaller gradually. Unevenness of the densitic curves for trabeculae in the alveolar bone became less with time. In the tibia unevenness of the densitic curves for trabeculae in the tibia became more pronounced with time and densitic curves for bone rose on the whole. The densitic curves for interosseous cortex and medial cortex in the tibia changed from unevenness to smoothness and approximated the pattern of controls. 4. Photo-densitically, density of alveolar bones of rats in the experimental group increased with time although difference was seen between the superior and inferior portions of the alveolar bone. Six weeks after the experiment, bone density for the superior portion for the experimental group increased to 0.78 and for the inferior portion to 0.83 with the value for controls as 1. In the tibia, interosseous cortex and medial cortex increased to 0.92 and 0.83, respectively, of controls four weeks after the experiment. Thereafter, increase in the value was seen, but the ratios decreased. 5. Histopathologically, thickening of bone layer was seen in the superior portion of the alveolar bone of the rats in the experimental group. In the inferior portion of alveolar bone, narrowing of the bone marrow due to thickening of bone layer and thickening of bone layer toward the periodontal membrane were seen. At the same time, Sharpey's fiber bundles also appeared. In the tibia, bone proliferation was seen from internal and external periosteum in interosseous cortex and medial cortex. However, fatty marrow did not improve until six weeks after the experiment. 6. Hematologically, ratios of electrolytic serum Ca to IP, and values of serum Na and Cl were very close to those of controls. However, values of serum IP and K were low. Biochemical CPK values, AL-P values and GOT values decreased to normal values, but GPT values varied up and down. On the basis of the foregoing findings, fragility of the alveolar bone and tibia due to osteoporosis at growing stage could be ameliorated considerably by dietary therapy. However difference remained in comparison with controls. As a means to overcome such difference, administration in combination with diet of calcitonin and activated vitamin D is recommended.
- 九州歯科学会の論文
- 1986-12-25