ヒト唾液の免疫学的研究

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The relationship between the local and the systemic immune response was considered by investigating the process producing each immunoglobuline in the domain of the oral cavity. Namely, the leukocyte, epithelial cell and secretory IgA (SIgA) in human saliva were examined in the healthy adults and the patients with periodontal disease. Using rats immunized with inactive Staphylococcus aureus 209p, the change in the immunoglobulin levels in the serum was examined by the week. 1. The number of the leukocytes was found to be highest in stimulating saliva by mastication followed by resting saliva and saliva in mouthwash saliva after taking of stimulating saliva in desending order for both the healthy adults and the patients with periodontal disease. 2. The average number of the leukocytes in resting saliva of the patients with periodontal disease was about 1.9 times and those in stimulating saliva and saliva in mouthwash saline were 3.1 and 1.7 times higher than those of the healthy adults. 3. The average number of epithelial cells in stimulating saliva was larger than those in resting saliva and saliva in mouthwash saline of both the healthy adults and the patients with periodontal disease. 4. The average number of epithelial cells in resting saliva of the patients with periodontal disease was about 0.7 times, that in stimulating saliva was 1.3 times and that in saliva in mouthwash saline was 1.1 times higher than those of the healthy adults. 5. The SIgA level in resting saliva of the patients with periodontal disease was 31.2±4.7 mg/ml and that of the healthy adults was 28.0±4.3 mg/ml. The level in stimulating saliva was lower than those in resting saliva of both the healthy adults and the patients with periodontal disease. 6. The IgG level in rat's serum after immunization with S. aureus 209p was 14.4±0.7 mg/ml in the 1st week ; 10.1±2.9 mg/ml, exceedingly low, in the 3rd week ; and gradually increased from the 4th week until the 6th week upto 16.7±2.3 mg/ml. Also, the IgM level in rat's serum was 0.58±0.08 mg/ml in the 1st week, and gradually increased to 0.71±0.06 mg/ml in the 6th week.
九州歯科学会の論文
1981-03-25

著者

安秉根
九州歯科大学歯科矯正学講座:九州歯科大学口腔細菌学講座

ヒト唾液の免疫学的研究

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