悪性腫瘍組織内の末梢神経線維に関する形態学的研究

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In regard to study in the malignant tumor, the changes nerve fiber in human cancer and in experimentation tumor has been put foward several theories, in other word, the previous report on nerve fibers in malignant tumor, there have been non-nerve distribution and conversely, there have been regenerated nerve fibers which have had influence upon the growth of tumors, the consensus has not yet been resolved. The author has studied nerve distribution in oral cancer tissues that operated by First Department of Oral Surgery Kyushu Dental College. In addition, oral tumor experimentation conducted by transplanting Vx7 carcinoma in the buccal region in rabbits to study the nerve fibers in the tumor. The following results were obtained. 1. On the nerve distribution, normal nerve fibers and degenerated nerve fibers were observed in the malignant tumors (nest, stroma). Normal nerve fiber could be found running far from or near the nest, nerve fibers that goes nest. Some nerve fibers that runs at times ramifies in stroma and comes to the nerve ending. The distinctive feature was that, some nerve distribution are traced along soft connective tissues around the cell group of the tumor, there imagined as if it resists infiltration of the tumor cell or as if by- passing it. 2. On the nerve number and size, normal nerve existed in stroma than in the nest. The experimental result made clear that the growth of the tumor and these nerve fibers are destroyed by the tumor cell. The sizes varied from simple nerve fibers or nerve fiber bundles, there are destroyed by the tumor cell in the early stages are not clear. 3. On the nerve ending and network, in the nest or stroma, ramifying simple free nerve ending were evident, however, no special nerve ending or network was found. The author believes that the special nerve endings or network are destroyed in an early stage and disappear from the tumor tissues. 4. On the neuro-vascular relationship, in the stroma blood vessels and capillaries are scattered but nerve fibers were accompanied by these a few blood vessels and capillaries. It is called neuro-vascular movement. 5. On the nerve degeneration, degenerated nerve fibers in malignant tumors have been found more in the nest than in stroma. The degeneration of stroma is mainly the deterioration of dyeing, swelling and creeping. With the malignant tumor outbreak, when connective tissue of the stroma starts to grow, a slight degeneration occurs. The degeneration characteristies of the nest are the strong creeping, hyperplasy, swelling, severance, vacuolar degeneration, granular degeneration, dissipation. As mentioned above the nerve fibers in malignant tumors undergo various changes. So the normal nerve fibers in tumors are proper nerve fibers or regeneration nerves, or whether they are causing some sort of affect upon the tumor is still doutful. It is difficult to determine through this study, but it is obvious that the active normal nerve fibers exist without being affected by tumor cell.
九州歯科学会の論文
1978-03-31

著者

小山巌
九州歯科大学口腔病理学教室:九州歯科大学第一口腔外科学教室

悪性腫瘍組織内の末梢神経線維に関する形態学的研究

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