カエル舌咽神経の再生に関する実験的研究

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In oro-maxillo-facial region, trauma or surgical operation occasionally cause injuries or amputations of the nerve fibers which do damage to sensibility, gustation or motion. The physiological and pathohistological experiments were performed in order to investigate the process of functional recovery and healing of the nerve fiber damaged. The frog's glossopharyngeal nerve which was cut off at the root of the tongue, was used for the experiment. The results obtained are summarized as follows : A. Physiological findings 1. By the 12th day after operation of the unilateral cutting of the glossopharyngeal nerve, the afferent impulses were not generated from the cut nerve by applicating tactile or chemical stimuli to the tongue. 2. By the 13th day after operation, one of the 4 subjects, responding to each stimulus, showed discharge of afferent impulses in the glossopharyngeal nerve of cut side. The other 3 subjects didn't show any response. 3. Among 42 subjects which elapsed from the 14th to the 20th day after operation, 33 subjects showed responses to both tactile and chemical stimuli and 5 subjects only to tactile stimuli. 4. Both frequency and amplitude of the afferent impulses in the early stage of recovery, were low and small, they, however, increased as time passed. B. Pathohistological findings 1. The degeneration in the peripheral nerve started by 24 hours after operation. 2. The degeneration was in process from the 3rd to the 6th day after operation, that is rosary-degeneration, laceration or granular decomposition were observed in all the layers and nerve fibers had disappeared in the fungiform papillae. 3. Waller's degeneraton seemed to have been completed from the 7th to the 10th day after operation. 4. By the 10th day after operation, swelling and proliferating Schwann's cells were seen lined up in the muscular layers, and were also seen one or two fine regenerated nerve fibers along Schwann's cell. 5. After the 15th day of operation, one or two fine regenerated nerve fibers were seen also in the fungiform papillae proceeding toward the sensory cell. With lapse of time regenerated nerve fibers increased in diameter as well as in number. 6. Even in the period of degeneration or regeneration, the sensory cells lying along the free edge of the fungiform papillae didn't show any change, instead, they were observed located regularly. C. Relation between physiological and pathohistological findings 1. The regenerated nerve fibers were pathohistologically observed in some muscular layers after the 10th day of operation, while it was after the 13th day of operation that physiological responses to the stimuli of the tongue could be observed. 2. The regenerated nerve fibers were seen in the fungiform papillae after the 15th day of operation, while the afferent impulses were observed by the 13th day after operation. As the regenerative process of the nerve fibers advanced with lapse of time, the afferent impulses of regenerated nerve increased in frequency and amplitude. 3. Pathohistologically, by after the 35th day of operation, the amount of destribution of the regenerated nerve fibers were scanty than the normal nerve fibers and that the impulses from the regenerated nerve fibers were of lower frequency and amplitude as compared to the nerve fibers of the normal side.
九州歯科学会の論文
1977-03-31

カエル舌咽神経の再生に関する実験的研究

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