排出管結紮顎下腺の変化に関する実験的研究

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Submandibular ducts on one side of jaws were surgically ligated with use of adult male rabbits and subsequent changes was observed macroscopically as well as pathohistologically for an extended period starting from one to 119 days after the operation. Findings obtained from the duct-ligated and antagonizing intact glands were compared with pictures of normal glands of control animals, and the results were summarized as follows. Changes of duct-ligated gland after operation A. Macroscopic findings The duct-ligated gland showed light pink swelling begining from one day after the operation, but the swelling gradually began to diminish by 7 days and turned hard in consistensy. B. Patho-histological findings 1. The first change to be observed was the degradation in the periphery of the gland involving degeneration, atrophy and necrosis of tissues, and this region of the gland began to be replaced by fibrous connective tissues by 7 days after the operation. 2. As for the mechanism of such destructive change to occur, the causative factors pushing forward the process are severe edema occurring in the peripheral part of the gland on one hand, and dilatation of the striated portion and small duct wall′s disruption on the other hand, all of these causing the glandular secretion to overflow and deposit in the intracellular spaces. 3. Similar changes did not occur in the middle of the gland, and instead there took place progressively dilatation of duct system and atrophy and eventual disappearance of alveoli. By about 21 days after the operation, a proliferative change began to be seen in the glandular epithelium which went on progressively. 4. This proliferative change of epithelium in duct system began to appear, after its initial atrophy and thining, with renewed vitality, and the proliferation proceeded mainly toward inside of duct, but partially toward the periphery of duct. The proliferated tissues that filled the inside space of duct and turned solid eventually constituted nest-like epithelial islands. 5. In a few cases of gland 70 days after the operation, there could be observed a small amount of alveoli newly generated in some part of the disintegrated glandular body. 6. The elastic fibers in the glandular body that normally encircle tightly outside of the duct and also were distributed densely between the interstitial connective tissue became progressively sparse and few in amount. 7. Cell infiltration mainly of acidophils was observed in the operated gland until 56 days after ligation of duct. Changes in the submandibular gland of opposite side whose duct was left non-ligated A. Macroscopic findings Like the submandibular gland of operated side, this gland too turned pink and edematous from the Ist day after operation. However, by 5 days after operation, the pinkish shade subsided and the gland recovered its normal hue. The gland, however, increased its size slightly until 21 days after operation. B. Histological findings On the first day of operation, a destructive change like that occurred in the ductligated gland was observed in the peripharal parenchyma. By the 3rd post-operative day, there could be seen the appearance of undifferentiated glandular cells. These cells groups could be discriminated into two types, of which the one was consisted of a population of small sized cells with high chromatin content, the other a population of large sized cells with light stainability. The former cells were to form the alveoli of the gland and the latter the striate portion and duct system.
九州歯科学会の論文
1973-05-31

著者

田村知治
九州歯科大学口腔病理学教室

排出管結紮顎下腺の変化に関する実験的研究

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