Relationship between Intracellular Ca^<2+> Store and Protein Kinase C in Agonist-Induced Contraction of Hypertensive Rat Aortae

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概要

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• The roles of intracellular Ca^<2+> store and protein kinase C (PKC) in vascular contractile responses independent of Ca^<2+> influx were studied using aortic rings from spontaneously hypertensive rat (SHR) and Wistar-Kyoto rat (WKY). The functional sizes of agonistsensitive intracellular Ca^<2+> store were estimated as the peak response to agonist after PKC inhibition with calphostin C (Cal-C), a PKC inhibitor. The participation of PKC in 5-hydroxytryptamine-, phenylephrine-, and endothelin-1 (ET-1)-induced contractions in aortae of SHR was equal to, or greater than in WKY. In contrast, compared with WKY, SHR aortae possessed a greater size of endothelin-1-sensitive Ca^<2+> store, a similar size of 5-hydroxytryptamine-sensitive Ca^<2+> store, and a smaller size of phenylephrine-sensitive Ca^<2+> store. Based on these data, both PKC activation and functional size of intracellular Ca^<2+> store differ between SHR and WKY and these differences are selective among agosists.

• 日本平滑筋学会の論文

著者

• Daniel E

  Mcmaster Univ. Ontario Can

• KWAN Chiu-Yin

  Smooth Muscle Research Program and Department of Medicine

• Shimamoto Hiroyuki

  Visiting Scientist From The First Department Of Internal Medicine Hiroshima University School Of Med

• Kwan Chiu-yin

  Smooth Muscle Research Program Division Of Physiology And Pharmacolgy Department Of Medicine Mcmaste

• SHIMAMOTO Yoriko

  Visiting scientist from PIA Nakamura Hospital

• DANIEL Edwin

  Smooth Muscle Research Program, Division of Physiology and Pharmacolgy, Department of Medicine, McMa

関連論文

• Membrane Abnormalities of Vascular Smooth Muscle of Mesenteric Arteries of Spontaneous Diabetic BB Rats
• Relationship between Intracellular Ca^ Store and Protein Kinase C in Agonist-Induced Contraction of Hypertensive Rat Aortae

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