コロイド滴定法による数種有機溶媒へのゼフィラミンの抽出率の測定

概要

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Colloid titration is one of the method of determining polyelectrolytes, by which the percent extraction of zephiramine (tetradecyldimethylbenzylammonium chloride) can be easily determined. A negatively charged colloid solution, PVSK (potassium polyvinylsulfate) was used as titrant, and toluidine blue as indicator. The mixture of 10 ml of zephiramine solution and 10 ml of an organic solvent was shaken for 30 minutes in a 30 ml stoppered test tube. After shaking, the mixture was allowed to stand for one hour. Five ml of the aqueous phase was taken into an Erlenmeyer flask, and titrated with N/400 PVSK solution. The end point was reached when the color changed from blue to red-violet. Benzene, toluene, 1,2-dichloroethane, chloroform, carbone tetrachloride and dimethylisobutyl ketone were examined as the organic solvent. Chloroform is the most favorable solvent for the extraction of zephiramine (above 90%). The values of the percent extraction of zephiramine in water-saturated and -unsaturated solvents indicate that a small amount of water contained in the organic solvent gives no effet on the extraction behavior. This method is also applicable to the mixed solvent, for example chloroform and carbone tetrachloride.
1976-08-10