誘導結合プラズマ質量分析法による生体試料中の微量白金の定量(<特集>質量分析法の応用技術)

概要

論文の詳細を見る
A method for the determination of trace levels of Pt in biological materials by ICP-MS was studied. A matrix effect caused by high concentrations of NaCl markedly reduced the ion intensity of Pt. Using In as an internal standard compensated for the matrix effect in NaCl solution and bovine serum. For the bovine serum samples (10-, 100- fold dilution and acid-digestion followed by 10-fold dilution), the In internal standard method provided an accurate value of 1 ng ml^-1 of Pt added to the serum. A polyatomic ion interference by HfO on the Pt determination was observed in the analysis of NIES Human Hair reference material, which contains a relatively high level of Hf. The proposed method was applied to the determination of Pt in liver, kidney and ascites fluid of a cis-platin administered rat. The analytical values were close to those obtained by ultrasonic nebulization-ICP emission spectrometry.
社団法人日本分析化学会の論文
1996-06-05