熱分析による純度測定法の精度及び適用範囲の改良に関する研究

概要

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A method is used in which the melting-point depression is determined by differential scanning calorimetry (DSC) and the purity of an organic compound is subsequently determined. This method has an excellent feature not found in other methods : it is not possible to determine the content of individual impurities, but is possible to accurately determine the content of the total amount of impurities, including the content of unknown impurities. However, this method can only be used to accurately determine the purity of substances that are present in quantities of approximately 98 mol% or more. A study of measurement and data-proceeding analysis methods by DSC has been conducted in order to expand the application range of this method, with which determinations are quickly obtained, and to find more partial methods that can provide results with good precision and accuracy. As the result of this study, a determination by the DSC method yields values with an error of ± 0.5 mol% for samples with a purity of 90 mol%. The technic described here improves purity determinations of organic compounds through the use of DSC.
社団法人日本分析化学会の論文
1999-04-05