心筋代謝に関する研究 : (I)実験的冠不全時の心筋代謝におよぼすα-リポ酸の影響について

概要

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With the purpose to study the mechanism of the action of α-lipoic acid in the coronary insufficiency, experiments were made on 25 dogs which had been brought to coronary insufficiency. By the technique of coronary sinus catheterization, the myocardial metabolism was investigated with regard to both organic acids and electrolytes. After the operation of coronary insufficiency, the uptake ratios of pyruvate, lactate, α-ketoglutarate and inorganic phosphate decreased, but they were found to increase after the injection of α-lipoic acid. The coronary arteriovenous difference in the concentration of K and Mg fell temporarily after the operation up to negative values, but it was restored by an injection of lipoic acid. This effect of α-lipoic acid lasted for about 7-28 minutes, when the uptake of pyruvate and α-ketoglutarate was remarkably increased. From the above results, it is considered that α-lipoic acid improves the myocardial metabolism by a rapid activation of TCA-cycle in the effect of promoted oxidation of α-keto acids and therefore may have an effective influence on the coronary insufficiency.
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