抗生物質の投与がビタミンB_1代謝におよぼす影響 : (III)オーレオマイシン, クロヽマイセチン, ストレプトマイシンおよびホモスルファミン投与のビタミンB_1代謝におよぼす影響, ことに肝静脈カテーテルによる観察

概要

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Daily administration of various antibiotics and homosulfamine was carried out for 6 days. Thiamine contents of blood, urine and feces were determined everyday, and then examination was made, using a liver catheter, on the behavior of administered thiamine. Intramuscular injection of streptomycin and oral administration of Aureomycin, Chloromycetin and homosulfamine caused disturbance of thiamine metabolism, especially of its phospholyration, and decrease of thiamine level of blood, while orally administered streptomycin had not such effects on the metabolism. However, fecal excretion of thiamine decreased remarkably in all cases. These results indicate that thiamine deficiency or its metabolic disturbance is not due to the inhibition of thiamine synthesis by intestinal bacteria, but to the action of antibiotics itself.
日本ビタミン学会の論文