L-アスコルビン酸の分解に関する研究 : (XVIII)細菌によるL-アスコルビン酸の分解機構 (7)デヒドロアスコルビン酸を経由する径路

概要

論文の詳細を見る
In the previous paper, it was presumed that one of the pathways of L-ascorbic acid metabolism might be carried through dehydroascorbic acid and diketo-L-gluconic acid. In this paper this pathway was studied more precisely. Glyoxal, glyoxlic acid and mesoxalic acid were not decomposed by L-ascorbic acid decomposing cells. Both dehydroascorbic acid and D-arabinosone were metabolized not by unadapted cells, but by L-ascorbic acid adapted cells slowly, and the latter metabolic rate was acceralated when a small quantity of glucose or L-ascorbic acid was added as hydrogen donators. From the finding that the volume of O_2 uptake for DL-glyceraldehyde (15μM) by L-ascorbic acid adapted cells was about half that of D-glyceraldehyde (15μM), it was presumed that perhaps L-glyceraldehyde was not metabolized. From the results above mentioned, the course via dehydroascorbic acid was presumed as follows : L-Ascorbic acid→dehydroascorbic acid→diketo-L-gulonic acid→(L-xylosone)→D-arabinosone→D-ribose.
日本ビタミン学会の論文