モルモット摘出心房におよぼす各種ビタミンB_1誘導体の影響
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概要
- 論文の詳細を見る
The effect of thiamine derivatives on the isolated guinea pig atrium was studied. The effect of thiamine derivatives was classified according to those structures into three groups : 1) TMP, TDP, TTP, BTMP had no effect on the isolated atrium. 2) The administration of such thiamine derivatives having-S-S-chains in the molecules, as TPD, TATD, TMD and TAD, increased the contractile force and decreased the beat rate. These compounds promoted recovery of atrium whose contraction had been stopped with acetyl cholin. 3) The administration of thiamine derivatives having-COR or-COOR with the OH-radicals, as OBT, BTDS and DBT, decreased the contractile force and the beat rate. When these compounds were administered to the isolated atrium whose contraction had been stopped with acetyl cholin, they showed sudden increase of the contractile force, immediately followed by the decrease.
- 日本ビタミン学会の論文
- 1970-07-25