ヒトの腸管を用いるビタミンB_<12>の吸収にかんする研究 : (I)経漿膜的に注入したビタミンB_<12>の吸収と内因子活性の腸管内分布

概要

論文の詳細を見る
Radioactive vitamin B_<12> in physiological doses was injected into the gut through the serosa during laparotomy and absorption was assessed by Schilling test. The doses injected into the small bowel were absorbed without added intrinsic factor to the extent comparable to that following oral administration, suggesting that intrinsic factor activity is present as far down as the ileocecal junction. Practically no absorption occurred to the doses applied in the colon below the ceceum where about one half of the doses were well absorbed and the addition of purified hog intrinsic factor abolished absorption. These data indicate that the large intestine, except the cecum, is not capable of absorbing physiological amounts of vitamin B_<12> as the small bowel and intrinsic factor has no role ; the cecum absorbs small doses of vitamin B_<12> under certain conditions, but not always, and this absorption does not involve intrinsic factor.
日本ビタミン学会の論文
1964-08-25