ビタミンB_2の組織化学的研究

概要

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Applying histochemical detection technique devised by our department, the distribution of riboflavin in animal ontogeny and phylogeny and moreover, in pathological materials of human cadavers and experimental CCl_4 toxicosis. The following results were obtained : 1. Characteristic distribution of riboflavin was noticed in each species in the animal kingdom, and then author discussed on the specificity of riboflavin distribution in each organ of living bodies on the phylogenitical view-point. 2. In higher animal the vitamin was found rich in such organs that enzymatic action of cells were excellent. 3. On the significance of riboflavin in eyeballs of aquatic animals, the author concluded that the optical function of riboflavin fluorescence played important role except enzymatic function. 4. In human embryo, a little riboflavin was found in early stadium, but the quantity of the vitamin were becoming more as embryo were growing up. 5. After describing the normal finding of riboflavin distribution in human being from the observation of sudden death cases such as apoplexy etc., the pathological pictures especialy on the case of hepatitis etc. were pointed out. 6. In the CCl_4 toxicosis the absorption of intestine was injured first, then the phosphorylation of the vitamin in liver cells and also reabsorption of epithelium of urinary tubules of the kidneys were injured.
日本ビタミン学会の論文