パントテン酸要求性大腸菌変異株の研究 : (I)パントテン酸要求株の性状とパントテン酸の定量

概要

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Pantothenic acid requiring mutants derived originally from E.coli 0-20 and strain W fell into three groups. The first group responded to pantoyl lactone, the second to β-alanine and the third only to intact pantothenic acid. Mutant 229 which required preformed pantothenic acid was available in the pantothenic acid assay study. In the synthetic medium of Davis and Mingioli supplemented with 0.5 per cent of casamino acids, this mutant showed regular response to the vitamin at a concentration ranging from 2.0 to 20 mμg per ml, and the dose-response curve was not affected by the presence of amino acids, B-vitamins, nucleic acids or their derivatives. Pantothenic acid content of several drugs determined with E.coli 229 was fairly consistent with that determined with L.arabinosus 8014.
日本ビタミン学会の論文