RUTINOTHIAMINEおよびCATECHOTHIAMINEの人体負荷実験

概要

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A reaction product thiamine and rutin, rutinothiamine (RT), and that of thiamine and pyrocatechol, cetechothiamine (CT), have hitherto been isolated in pure crystalline forms, and were shown to have similar chemical properties. The absorbability of both RT and CT from human intestine was tested by giving to a healthy adult maintained on a diet strictly constant in composition, and was compared with that of both thiamine and thiamine propyl disulfide (TPD). Each material was given orally once in the morning (8.00 a.m.) with the interval of 2-3 days and the urinary and fecal excretion of the vitamin in 24 hours as well as the vitamin level in blood at 10 a.m. were determined every day. The absorbability of both CT and RT was found to be better than thiamine but poorer than TPD. Penetration into human blood cells was also tested in vitro, and CT and RT were found to enter the cells in small amounts but thiamine failed to enter. On the contrary, thiamine propyldisultide was found to penetrate into the cells markedly. The above findings have led to the assumption that CT and RT are the same substance or the substances very similar both in chemical and biological properties.
日本ビタミン学会の論文