注射で与えた放射性Hydroxocobalaminの排泄と組織取込み : シロネズミによる実験

概要

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^<57>Co-labeled hydroxocobalamin (OH-B_<12>) and ^<57>Co- or ^<60>Co-cyanocobalamin (CN-B_<12>) were injected to rats by subcutaneous and intravenous routes and tissue distribution and excretion of radioactivity were measured. It was found : 1) OH-B_<12> was taken up to a greater extent than CN-B_<12>, particularly by the liver, kidney and pancreas. 2) The highest uptake occurred in the kidney which was not directly related to urinary excretion. 3) Unlike other organs, the liver radioactivity increased for several days after administration. 4) The excretion of OH-B_<12> was similar to that of CN-B_<12>, the feces being the major excretory route for physiological doses. The urinary excretion increased with the dose given and less OH-B_<12> was lost by this route than CN-B_<12>.
日本ビタミン学会の論文
1966-05-25