醗酵乳酸の利用に關する研究 (第5報) : 氣一液相反應に於ける乳酸メチルエステルの製造 (3) 半連續型式

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We studied the formation of methyl lactate by the semicontinuous system. 1 M of lactic acid (60% strength) was taken in a reaction vessel placed in a boiling water bath, and then vapour of methanol was passed through the acid in the acid in the vessel at a rate of about 3.85 gr. per min.. After the reaction started, 1 or 2 M of lactic acid (60% strength) were added from a uniformly dropping burette at the desired time. The product containing ester, water and methanol was continuously distilled and collected in flasks through a cooler. The results were as follows : 1) The best result was obtained by adding the lactic acid to the reaction mixture after 1 hr from the start of the reaction, which follows on the almost complete removal of water from the solution.2) It was desirable to add the lactic acid at a rate of about 1.65 gr per min.. At this rate, the percentage of the distilling ester would be kept nearly constant.3) It was most effective when the concentrations of H_2SO_4 in the mother lactic acid and in the added lactic acid were 6.2 gr and 5.1 gr per 1 M, respectively.4) Although the amount of the lactic acid to be added varied with the amount of impurities contained in the fermentation lactic acid, it was generally limited to about 1.5 M.5) Compared with the batch and the continuous system, this semicontinuous system seems to be most excellent.
社団法人日本生物工学会の論文
1955-07-15