マウス移植乳癌の増殖およびウレタン誘発肺腫瘍に対するニコチンアミドの抑制効果

概要

論文の詳細を見る
Nicotinamide, an antipellagratic vitamin, significantly suppressed urethane-induced malformations in mice. In the present study, effects of nicotinamide were examined on the growth of transplanted murine breast adenocarcinoma C3H/HeJ #8, which originated spontaneously in this strain, and urethane-induced lung tumorigenesis in JCL : JCR mice. Nicotinamide also showed potent antitumorigenic effects, when it was given with diet immediately after urethane treatment (1 mg/g, s.c.) or the tumor transplantation (s.c.). The level of inhibition was proportional to the dose of nicotinamide in diet, that is 48.5 and 72% for tumor weights (2.5 and 5.0% in diet), and 20.7, 54.6 and 65.2% for lung tumor (1.0, 2.5 and 5.0%), respectively. Furthermore antiteratogenic and antitumorigenic effects of nicotinamide were also significant even when it was given 2-4 or 10-20 days after urethane treatment, and 14 days after tumor transplantation. Nicotinamide seems to act directly on the organs, fetus, placenta and tumor tissues as nicotinamide itself or NAD^+, but not as nicotinic acid, since only nicotinamide and small amount of NAD^+ were detected chromatographically. The mechanism of the suppressing effects of nicotinamide on the teratogenesis and tumorigenesis has been discussed.
日本ビタミン学会の論文
1993-09-25