リポ酸脱水素酵素の機能の多様性
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概要
- 論文の詳細を見る
Lipoamide dehydrogenase contains FAD and redox-acitve disulfide in its active center. The enzyme accepts two electron or four electrons under various conditions. In this paper we describe the electron transfer reaction mechanisms of NADH : lipoate reductase, NADH :osygen reductase, and NADH : menadione reductase. The enzyme catalyzed a mixed one-electron and two-electron reduction of oxygen and menadione, the two-electron transfer mechanism being dominant. The oxidase reaction is associated with fully-reduced flavin, and the menadione reductase reaction with half-reduced flavin. Furthermore, the superoxide radical generated by various reactions of the enzyme can reduce consecutively ferritin iron.
- 日本ビタミン学会の論文
- 1993-06-25