(3)脊椎動物のモノADP-リボース化反応
スポンサーリンク
概要
- 論文の詳細を見る
NAD is involved in the numerous metabolic reactions as a major coenzyme. Further, NAD is known as the ADP-ribose donor for the covalent modifications (mono-and poly-ADP-ribosylation) or the synthesis of a signaling molecule, cyclic ADP-ribose. Mono-ADP-ribosylation is a posttranslational modification in which the ADP-ribose moiety of NAD is transferred to target amino acid residues in the proteins or peptides. Bacterial toxins, such as chorela and pertuissis, include mono-ADP-ribosyltransferase activity and modify the crucial cellular proteins Gsa and Gioc, thereby resulting in the disturbance of cellular function. Mono-ADP-ribosyltransferases have been detected not only in bacteria but also in eukaryotes, and vertebrate ADP-ribosyltransferases have been identified in various tissues and cells. In this review, we have highlighted and outlined the arginine-specific ADP-ribosyltransferases 'Arts' in vertebrates, and discussed the possible roles of Arts in cellular functions. We have also described newly identified chicken glycosylphosphatidylinositol (GPI)-anchored Arts. Vertebrate Arts, and ADP-ribosylarginine hydrolases which cleave ADP-ribose-arginine linkage on the protein, are constitutively expressed on cells and may play critical roles for various cellular functions via ADP-ribosylation and de-ADP-ribosylation cycle. Recent research developments in the ADP-ribosylation would disclose its involvement in cellular processes in the near future.
- 日本ビタミン学会の論文
- 2004-07-25
著者
関連論文
- DP-171-5 選択的p38 MAPK阻害剤・FR-167653を用いた肝線維化予防実験(第108回日本外科学会定期学術集会)
- フェンタニルによるμオピオイド受容体インターナリゼーションの検討
- 第81回生涯教育講座 高脂血症薬ニコチン酸とメタボリック シンドローム
- 2-III-1 動物における組織特異的NAD生合成経路の存在の検討(第56回大会一般研究発表)
- 2-II-26ヒトNADシンテターゼのドメイン構造の解析(第55回大会一般研究発表)
- T細胞アロ抗原RT6のグルタミン酸207のアルギニン特異的ADP-リボシル化反応における役割
- シンポジウムNADの多様な役割
- (3)脊椎動物のモノADP-リボース化反応
- 脊椎動物のモノADP-リボース化反応(シンポジウム「NADの多様な役割」)
- げっ歯類中枢神経系におけるADP-リボシルアルギニン水解酵素の局在の免疫組織学的検討
- ニワトリ多形核白血球ADP-リボシル転移酵素の細胞外放出について
- ニワトリ脾臓膜画分に存在するGPI-アンカー型アルギニン特異的ADP-リボシル転移酵素の精製と性質
- 脊椎動物のアルギニン特異的ADP-リボシル転移酵素とその内在性標的タンパク質
- ヒトNAD生合成経路酵素群の分子同定 (トリプトファン研究会記録)