Nicotinamide adenine dinucleotideの代謝にかんする研究

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概要

• 論文の詳細を見る

• The metabolism of NAD was investigated with mice following the administration of NAD- (nicotinamide-7^<14>C) and NAD-(adenosine-U^<l4>C). When NAD was given intravenously, it was not utilized directly as a coenzyme, and was degraded immediately to nicotinamide and presumably to adenosine diphosphate ribose. The ADP-ribose moiety was converted rapidly to ADP, AMP, ATP and two unknown metabolites. Even 20 seconds after the injection of NAD-(nicotinamide-7^<14>C) , more than 90% of radioactivity in the blood was shown to be nicotinamide. The nicotinamide disappeared rapidly from the blood and was incorporated into various tissues and organs. In addition, a portion of nicotinamide was excreted into the gastrointestinal tract. The radioactive material was reabsorbed and reutilized as a precursor to NAD in various tissues. When NAD-(nicotinamide-7^<14>C) was given orally, it was shown to be degraded to nicotinamide. The latter compound was absorbed efficiently and distributed in every tissue and organ. Practically no radioactivity was found in the feces. About 20% of total radioactivity was expired as ^<14>C0_2 Whithin 8 hours. Probably, the intestinal bacteria were responsible for this complete degradation of the nicotinamide.

• 日本ビタミン学会の論文
• 1969-07-25

著者

• 市山 新

  京都大学医学部医化学教室

• 市山 新

  京都大学医学部医科学教室第一講座

• 根岸 嗣治

  京都大学医学部医科学教室第一講座

関連論文

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• Coenzyme Qの吸収と排泄にかんする研究
• 4.脳におけるNicotinamide adenine dinucleotideの生合成(第169回会議研究発表要旨)
• 15.In vivoにおけるNicotinamide adenine dinucleotideの生合成(I) : ニコチン酸アミドの意義(第156回委員会研究発表要旨)
• Nicotinamide adenine dinucleotideの代謝にかんする研究

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