肝リン脂質に及ぼすビタミンB_2の影響

概要

論文の詳細を見る
The changes of phospholipid metabolism in rat liver were investigated when riboflavin or its butylester was administered orally. The amount of liver phospholipid did not change in either free or butylester of riboflavins administration. The incorporation rate of ^<32>P into phospholipid fraction was found to be maximum after 24 hrs. in riboflavin administration but it was 48 hrs. in butyrate. On the other hand, specific activity of phospholipid fraction of both groups were maximum at 48 hours. Phosphatidylcholine and phosphatidylethanolamine fraction. showed high radioactivities and these tendencies were found remarkably in the groups of butyl ester. Phosphatidylcholine concenrtation was found to be increased by administration of large amount of butylester. From these results, it suggests that the administration of riboflavin induces the increase of turnover of phospholipid in the liver and the phosphorylation process of phospholipid is coupled with that of riboflavin and elevetion of specific activity of phosphatidylcholine fraction play an important role for the regulation of fatty acid metabolism in the organs, such as liver and blood vessels.
日本ビタミン学会の論文
1969-01-25