炭酸ガス分壓に對する呼吸反應 : いわゆる呼吸中樞感受性について
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概要
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In sixteen hospitalized patients without cardiopulmonary disease (a control group), six patients with pulmonary diseases, five patients with myxedema and sixteen cardiac patients, the so-called sensitivity of the respiratory center to the carbon dioxide and hydrogen ion stimulus has been determined by relating effective alveolar ventilation to changes in arterial CO_2 tension and hydrogen ion conentration induced by CO_2 inhalation.1) In the control group (VA/m^2)/(Pa_<CO_2>) was within the range of 0.39 to 0.9 1./min./m^2/mm. Hg and (VA/m^2)/((H^+)a) was within the range of 0.6 to 1.2 1./min./m^2/10^<-9> mole/1.2) Three patients with emphysema (group III, IV after Baldwin's classification) and one patient with myxedema revealed a reduced sensitivity as compared with the normal control group. In this reduction of sensitivity, in emphysema, acclimatization to the increase of arterial carbon dioxide pressure seemed to be the chief causal element and sometimes mechanical impairments of breathing might have play a part. In myxedema, hypofunction of the thyroid which is a link in the adrebal sympathetic system seemed to be an important factor.3) Cardiac patients, especially in the presence of congestive heart failure, revealed an increased sensitivity as compared with the control group. In such increase of sensitivity, acclimatization to the decrease of arterial carbon dioxide pressure seemed to be the important causal element. Metabolic acidosis and others were discussed.
- 社団法人日本循環器学会の論文
- 1959-04-20